Biosynthesis of digitoxin in Digitalis purpurea []. Deluca, M.E. Seldes, A.M. Gros, E.G. (Departamento de Quimica Organica, Universidad de Buenos Aires. Download Citation on ResearchGate | Biosynthesis of digitoxin in Digitalis purpurea | Simultaneous administration of a mixture of [H]-3β. Deluca M.E.; Seldes A.M.; Gros E.G., Biosynthesis of digitoxin in digitalis purpurea.

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Planta Medica 46 2: Unlike digoxin which is eliminated from the body via the kidneysit is eliminated via the liver, so could be used in patients with poor or erratic kidney function. Ceskoslovenska Farmacie 2 Alcoholic glycoside Cardiac glycoside Bufadienolide Cardenolide Cyanogenic glycoside Glycosylamine Phenolic glycoside Anthraquinone glycoside Coumarin glycoside Flavonoid glycoside Saponin Steviol glycoside Thioglycoside.

The modern therapeutic use of this biosynthedis was made possible by the works of the pharmacist and the French chemist Claude-Adolphe Nativelle The first structural analysis was done by Adolf Otto Reinhold Windaus inbut the full structure with an exact determination of the sugar groups was not accomplished until Journal of Pharmacy and Pharmacology 8 Digitoxin is a cardiac glycoside.

Comparative study of the biology of digitalis lanata digitalis ambigua digitalis purpurea and a digitalis purpurea inoculated population. Studies in the genus Digitalis.

PDF of Biosynthesis of digitoxin in digitalis purpurea

Cardiac glycosides and cancer therapy”. Antidigoxin antibody fragments, the specific treatment for digoxin biosunthesis, are also effective in serious digitoxin toxicity.


In other projects Wikimedia Commons. Annales Pharmaceutiques Francaises 25 Comparative investigation of the biology of Digitalis lanata, Digitalis ambigua, Digitalis purpurea and Digitalis purpurea grafted population.

Biosynthesis of digitoxin in Digitalis purpurea [1989]

Studies digitocin the production of Digitalis cardenolides by plant tissue culture. Arenobufagin Bufotalin Cinobufagin Marinobufagin. Plant and Cell Physiology 23 7: The colorimetric estimation of digitoxin and of preparations of Digitalis purpurea.

Chemistry of natural compounds: Digitoxin exhibits similar toxic effects to the more commonly used digoxinnamely: Oswald Schmiedeberg was able to obtain a pure sample in Determination of digitoxin and other glycosides and genins in Digitalis purpurea.

Biotransformation of digitoxin by suspension callus culture of Digitalis purpurea. Incidence and biosynthesis of digitoxjn in tissue cultures of Digitalis purpurea and Digitalis lanata.

Quantitative determination of digitoxin and gitoxin in digitlxin leaves of Digitalis purpurea. Enzymatic glucosylation of digitoxin by particle enzyme fractions of Digitalis purpurea.

O-glycosidic bond N-glycosidic bond S-glycosidic bond C-glycosidic bond. With Practical Remarks on Dropsy and other Diseases. Khimiko-Farmatsevticheskii Zhurnal 5 Effects of nutrients on digitoxin formation by shoot-forming cultures of Digitalis purpurea L. Determination of the digitoxin content of Digitalis purpurea. It is a phytosteroid and is similar in structure and effects to digoxin though the effects are longer-lasting. Journal of Pharmacy and Pharmacology 4 Digitoxin and related cardenolides display potent anticancer activity against a range of human cancer cell lines in vitro but the clinical use of digitoxin to treat cancer has been restricted by its narrow therapeutic index.

International Journal of Clinical Pharmacology and Therapeutics. Studies on the production of digitalis cardenolides by plant tissue culture 3.


Digitoxin – Wikipedia

While several controlled trials have shown digoxin to be effective in a proportion of patients treated for heart failure, the evidence base for digitoxin is not as strong, although it is presumed to be similarly effective. Biosynthesis of digitalis glycosides. This page was last edited on 20 Septemberat However, it is now rarely used in current Western medical practice.

Planta Medica 17 4: The Yale Journal of Biology and Medicine. Ouabain g-Strophanthin k-Strophanthin Cymarin. European Journal of Clinical Investigation. Quantitative determination of digitoxin and gitoxin in digitalis purpurea.

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Planta Medica 29 3: Industrial lyophilization tests of medicinal plants vi purple digitalis d digitalis purpurea d digitoxin glucoside. Cardenolides in surface-cultures of cotyledones and leaves of Digitalis purpurea.

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Bufo Arenobufagin Bufotalin Cinobufagin Marinobufagin. Investigations on the biosynthesis of digitalis d glycosides enzymatic glycosylation of digitoxin by a particulate enzyme fraction of digitalis purpurea d.

Biosynthesis of digitoxin in digitalis purpurea. Transl9 5 ,