Request PDF on ResearchGate | Dermatitis granulomatosa intersticial con artritis | —Interstitial granulomatous dermatitis with arthritis is a systemic disease. La dermatitis granulomatosa intersticial con artritis es una enfermedad sistémica que afecta a la piel y al sistema musculosquelético. Esta nueva entidad se. Summary. An Orphanet summary for this disease is currently under development. However, other data related to the disease are accessible from the Additional.

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Granulomatous dermatitis describes several disorders characterised by their histological appearance. Interstitial granulomatous dermatitis is a rare skin disorder in which there is a particular pattern of granulomatous inflammation.

However, several different types of rash have been described with the same histological appearance. Branulomatosa features of interstitial granulomatous dermatitis are variable.

Interstitial granulomatous dermatitis is diagnosed by a pathologist on examining a skin biopsy dermatopathology. The characteristic histological features of interstitial granulomatous dermatitis are:. Granuloma annulare and interstitial granulomatous dermatitis may appear similar clinically and histologically.

Granuloma annulare also presents with papules and plaques but these are typically on the back of the hands or feet, whereas the trunk is a more common site for interstitial granulomatous dermatitis.

Granuloma annulare is less often associated with auto-immune diseases.


The characteristic histological features of granuloma annulare are:. Palisading neutrophilic granulomatous dermatitis was first described as crusted umbilicated papules on the elbows arising in patients with rheumatoid arthritis Winkelmann granuloma and Churg-Strauss disease. Several different types of rash have been described with the same histological appearance including annular plaques on the trunk.

Lesions are often tender and may ulcerate. Palisading neutrophilic granulomatous dermatitis is diagnosed on skin biopsy. The characteristic histological features of palisading neutrophilic granulomatous dermatitis are:. Flame figures are also seen in the pathology of Wells syndrome. Several conditions have been noted to arise in association with interstitial granulomatous dermatitis. There is less information about associations with palisading neutrophilic granulomatous dermatitis.

Both forms of granulomatous dermatitis have often arisen in people with other conditions considered autoimmune in origin, implying an immune-complex mechanism may be involved in the pathogenesis. There are some reports of association of malignancy with interstitial granulomatous dermatitis.

In once case, the lesions cleared after lung cancer was treated. Granulomatous dermatitis typically intersticiwl and remits. Intersticiao treatments have included:.

Granulomatous dermatitis | DermNet NZ

One case associated with SLE responded well to systemic steroids after 15 days. Although TNF-inhibitors have been recently described as inducing interstitial granulomatous dermatitis7 etanercept has been used in interstitial granulomatous dermatitis associated with rheumatoid arthritis with complete skin clearance and improvement in arthritis. Interstitial granulomatous dermatitis induced by medications is known as interstitial granulomatous drug reaction. It is thought to be a grxnulomatosa clinical and pathological entity.


It dermtitis as annular plaques on the arms, medial thighs and skin folds. The rash resolves when the responsible drug is withdrawn.

Interstitial granulomatous drug reaction is diagnosed by skin biopsy. The characteristic histological features of interstitial granulomatous drug reaction are:.

Granulomatous dermatitis

Medications that have been reported to be implicated in interstitial granulomatous dermatittis eruption include:. Self-skin examination New smartphone apps to check your skin Learn more Sponsored content. DermNet NZ does not provide an online consultation service. If you have any concerns with your skin or its treatment, see a inteersticial for advice. Am J Dermatopathol ; 33 8: Interstitial granulomatous dermatitis with cutaneous cords and arthritis: A disorder associated with autoantibodies.

J Am Acad Dermatol ; Ann Dermatol Venereol ; Interstitial granulomatous dermatitis secondary to acute promyelocytic leukemia. Am J Dermatopathol ; 30 2: Interstitial granulomatous dermatitis associated with the use of tumor necrosis factor alpha inhibitors. Interstitial granulomatous dermatitis in rheumatoid arthritis responsive to etanercept.

Clin Rheumatol