In the past decade, HIFU ablation has emerged as a modality for palliative treatment of pancreatic tumors. Multiple preclinical and non-randomized clinical trials. HIFU appears to be an effective tool for pain palliation in advanced pancreatic cancer. Studies assessing treatment in patients with pancreatic. Request PDF on ResearchGate | HIFU for Palliative Treatment of Pancreatic Cancer | High intensity focused ultrasound (HIFU) is a novel.

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The patients fasted beginning the night before a HIFU procedure and the placement of a nasogastric hifi was required prior to two HIFU treatment sessions in order to remove gas from the stomach that was obscuring the tumor. Khokhlova and Joo Ha Hwang. There were no patients who had a complete response, However, several studies have reported that HIFU can also induce cell apoptosis through hyperthermia, i.

Concurrent gemcitabine and high-intensity focused ultrasound therapy in patients with locally advanced pancreatic cancer. In HIFU the majority of heat deposition occurs at the focal area, where the treaatment is the highest.

Footnotes No potential conflict of interest. Chin J Clin Hep. Shock-induced heating and millisecond boiling in gels and tissue due to high intensity focused ultrasound.

The main factors that impact the efficacy of HIFU for pancreatic tumors includes an adequate acoustic window, limited respiratory movement of the tumor and dose of HIFU energy delivered. In addition, there is an electrical teratment system and water treatment system not pictured.

He underwent HIFU ablation of the primary tumor in only one session. Therefore, it is critical to evacuate the gas in the stomach and colon if possible. Pain response was routinely assessed during follow-up visits using a numeric pain scale After day one of the second cycle, treatment was delayed because of thrombocytopaenia, and definitively discontinued because of unstable clinical status for acute lower limb peripheral neuropathy and appearance of upper abdominal pain.


The main parameters that are used to describe an ultrasound wave are its frequency, or the number of pressure oscillations per second, and pressure amplitude, as illustrated in Figure 2C. On 21st of March,the patient palliaative the Specialized Clinical Center for non-invasive treatment with HIFU, with abdominal pain, measured 7 out of 10 points on the visual analog scale, and was given non-opioid pain medication.

HIFU for Palliative Treatment of Pancreatic Cancer.

The patient is currently on chemotherapy, asymptomatic with a good performance status. In addition, there is an electrical power system and water treatment system not pictured. This approach would be particularly beneficial in obese patients. We report a case of a year-old man with a metastatic anaplastic pancreatic carcinoma APC. Marmottant P, Hilgenfeldt S. The other 45 patients Substantial tumor-related pain reduction was achieved in most cases after HIFU treatment, and no significant side-effects were observed.

Theory of Focusing Radiators. A majority of patients diagnosed with pancreatic cancer have advanced disease at the time of diagnosis and are not amenable for surgery with intent panceatic cure. All Published work is licensed under a Creative Commons Attribution 4. Orsi F et al High-intensity focused ultrasound ablation: In general it could even improve overall survival OS.

In that case the temperature rise is too rapid for protein denaturation to occur, but the interaction of the large boiling bubble with ultrasound field leads to complete tissue lysis, as illustrated in Figure 3C A A single-element HIFU transducer has a spherically curved surface to focus ultrasound energy into a small focal region in which ablation fot place, leaving the surrounding tissue unaffected.

During the last decade, high intensity focused ultrasound HIFU has been introduced as an innovative non-invasive method for thermal ablation of foor and malignant solid tumors. Chin J Gen Surg. Clinical studies As mentioned above, most patients diagnosed with pancreatic cancer are considered inoperable and systemic chemotherapy has only modest effect. The energy of the incident ultrasound wave is transferred very efficiently into stable oscillation of resonant-size bubbles.


HIFU for Palliative Treatment of Pancreatic Cancer.

Contrast enhanced-CT scan of a year-old male demonstrating a tumor in the body of the pancreas prior to high intensity focused ultrasound therapy a. Pancfeatic -6 dB focal dimensions are 8 mm in length and 3 mm in diameter.

This changes the course of treatment dramatically: Gauging the likelihood of cavitation from short-pulse, low-duty cycle diagnostic ultrasound.

Context Pancreatic cancer is one of the most aggressive malignant diseases in which the survival rate has not improved in the past 40 years. An illustration of how HIFU therapy is administered for ablation of pancreatic tumors is provided in Figure 1. The interval spacing in the x-y plane is mm. The thermal hypothesis of the mechanism of ultrasonic focal destruction in organized tissues. Controlled tissue emulsification produced by high intensity focused ultrasound shock waves and millisecond boiling.

Effects of nonlinear propagation, cavitation, and boiling in lesion formation by high intensity focused ultrasound in ov gel phantom. In blood vessels, violently collapsing bubbles can damage the lining of the vessel wall or even disrupt the vessel altogether. Twoyear survival paliative was as follows: In order to relieve the symptoms and provide better quality of life, palliative procedures and chemotherapy are usually offered to patients who are not appropriate for curative surgery.