INFeD® improved the hemoglobin response to erythropoietic therapy in have been reported after administration of iron dextran injection, the drug should be. iron dextran – Drug Summary. Jump to INFeD Intramuscular Inj Sol: 1mL, 50mg . INFeD: INFeD is administered by intramuscular or intravenous injection. Allergan, Inc.: Intravenous or intramuscular injections of INFeD are indicated for treatment of patients with documented iron deficiency in whom.

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Iron therapy in these patients should be directed toward replacement of the equivalent amount of iron represented in the blood loss. Iron packagw of hemoglobin.

Most patients with chronic kidney disease will require supplemental iron e. The first stage involves an inflammatory reaction at the site of injection which aids the passage of the drug into the lymphatic system. Specific guidelines for dosage adjustments in hepatic impairment are not available. Patients with a significant history of allergies e. A stable complex is formed that prevents iron from entering into further chemical reactions. Anaphylaxis and other hypersensitivity reactions have been reported after uneventful test doses as well as therapeutic doses of iron dextran injection.

Epinephrine should be immediately available in the event of acute hypersensitivity reactions. Factors contributing to the formula are shown below. Major In general, oral mineral supplements should not be given since they may block the oral absorption of trientine.

INFeD should be injected only into the muscle mass of the upper outer quadrant of the buttock — never into the arm or other exposed areas — and should be injected deeply, with a 2-inch or 3-inch 19 or 20 gauge needle. Individual doses of 2 mL or less may be given on a daily basis until the calculated total amount required has been reached.

If test dose uneventful, give the remainder of the total dose as mg of elemental iron per day IM or slow IV until the total calculated dose is given. Uptake by these cells occurs at a rate of about 10—20 mg per jnsert. Although there are significant variations in body build and weight distribution among males and females, the accompanying table and formula represent a convenient means for estimating the total iron required.


Do not administer iron dextran to patients with evidence of iron overload e. Periodic hematologic determination hemoglobin inesrt hematocrit is a simple and accurate technique for monitoring hematological response, and should be used as a guide in therapy.

Although serum ferritin is usually a good guide to body iron stores, the correlation of body iron stores and serum ferritin may not be valid in patients on chronic renal dialysis who are also receiving iron dextran complex. Iron Replacement for Blood Loss: The extent of risk for anaphylactoid reactions to any specific iron infrd product is unknown and may vary among oackage.

Iron dextran (INFeD)

If supine, the patients should be in a lateral position and the injection should be into the upper-most part of the buttock. Major Deferasirox chelates iron and is indicated as a treatment of iron toxicity or overdose. Consult specialized references for amount of test dose to be given. Inset dextran should be administered to pregnant women only if the benefits outweigh the potential risks to the fetus. Patients with hepatic disease should receive iron dextran with caution.

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Administration of iron does not stimulate the production of red blood cells, nor does it correct abnormalities not caused by iron deficiency.

The total amount of INFeD in mL required to treat the anemia and replenish iron stores may be approximated as follows:. Am J Kid Dis. The test dose should be administered in the same recommended test site and by the same technique as described in the last paragraph of this section. INFeD should not normally be given in the first four months of life. Patients should be monitored for signs and symptoms of anaphylactic-type reactions during all iron dextran administrations.

Inject deeply into the upper outer quadrant of the buttock gluteus maximus only using a 2- or 3-inch, or gauge needle. Epinephrine should be immediately available. Iron stores are utilized in erythropoiesis and can be depleted during therapy even in patients with normal pre-treatment iron concentrations.


The formula shown below is based on the approximation that 1 mL of normocytic, normochromic red cells contains 1 mg of elemental iron: Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit.

An In Vitro Study. To restore hemoglobin and replenish iron stores in iron-deficiency anemia due to causes other than blood loss.

Alternatively the total dose may be calculated: Fatal anaphylactic reactions are possible. Moderate The concomitant packae of angiotensin-converting enzyme inhibitors ACE inhibitors with iron dextran may increase the risk for anaphylactic-type reactions.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever the solution and container permit. If test dose uneventful, infuse the remainder of the total calculated dose IV over 2 to 6 hours.

Iron dextran (INFeD) | – A Hematology Oncology Wiki

Achieving and maintaining adequate iron stores are essential to attaining an optimal response to MPG-epoetin beta. Anemia, hemochromatosis, hemoglobinopathy, hemosiderosis. Some patients with chronic hepatic disease may also have hemochromatosis or moderate iron overload in hepatic tissues.

Therapeutically, it is typically illogical for a patient to receive both iron supplementation e. Related Drug Information Drug Summary. Normal hemoglobin males and females over 15 kg 33 lbs. Transferrin eventually becomes available for reuse. INFeD is administered by intramuscular or intravenous injection. Each 1 mL of iron dextran lackage contains innfed mg of elemental iron.

If test dose uneventful, give the remainder of the total dose as mg elemental iron per day IM or IV until the total calculated dose is given. Iron dextran injection contains 50 mg of elemental iron per mL.